Maxicuma® was evaluated for safety through acute single and repeated dose toxicity studies. 2 preclinicals and safety studies have been conducted to evaluate the safety of Maxicuma®, and two clinical trials have been conducted without any adverse events. Further, it is certified for self-affirmed GRAS (Generally Recognized as Safe) by convening a scientific expert review panel. The GRAS dosage for functional food and beverages is 50 mg per serving.